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Assay Detail

CHEMBL1019538

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Binding
Inhibition of Plasmodium falciparum PFT
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: a comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity.
Gupta MK, Prabhakar YS.
Eur J Med Chem (2008) 43 : 2751 -2767
PubMed 18329140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 8.28 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193034 1 9.40
CHEMBL181102 1 9.22
CHEMBL182888 1 9.22
CHEMBL365742 1 9.10
CHEMBL183536 1 9.05
CHEMBL370298 1 8.96
CHEMBL194447 1 8.92
CHEMBL373337 1 8.85
CHEMBL191843 1 8.82
CHEMBL192244 1 8.55
CHEMBL192898 1 8.10
CHEMBL195168 1 7.60
CHEMBL193161 1 7.55
CHEMBL233288 1 7.38
CHEMBL365549 1 7.26
CHEMBL371408 1 6.78
CHEMBL372017 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193034 IC50 = 0.3981 nM 9.40
CHEMBL181102 IC50 = 0.6026 nM 9.22
CHEMBL182888 IC50 = 0.6026 nM 9.22
CHEMBL365742 IC50 = 0.7943 nM 9.10
CHEMBL183536 IC50 = 0.8913 nM 9.05
CHEMBL370298 IC50 = 1.096 nM 8.96
CHEMBL194447 IC50 = 1.202 nM 8.92
CHEMBL373337 IC50 = 1.413 nM 8.85
CHEMBL191843 IC50 = 1.514 nM 8.82
CHEMBL192244 IC50 = 2.818 nM 8.55
CHEMBL192898 IC50 = 7.943 nM 8.10
CHEMBL195168 IC50 = 25.12 nM 7.60
CHEMBL193161 IC50 = 28.18 nM 7.55
CHEMBL233288 IC50 = 41.69 nM 7.38
CHEMBL365549 IC50 = 54.95 nM 7.26
CHEMBL371408 IC50 = 165.96 nM 6.78
CHEMBL372017 IC50 = 1000.0 nM 6.00