Compound Detail
CHEMBL233288
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Cn1cncc1CN1CC(N(CC(=O)NC(C)(C)C)S(=O)(=O)c2ccc(F)cc2)Cc2cc(C#N)ccc21
Basic Information
| ChEMBL ID | CHEMBL233288 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GKDUCVUJDGMMBX-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
538.6
MW (Da)
2.97
ALogP
7
HBA
1
HBD
111.3
PSA (Ų)
0.50
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.12 | 7.6267 | 7.6 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 7.586 | nM | 8.12 | Inhibition of rat PFT | 18329140 |
| Unchecked | IC50 | = | 42.0 | nM | 7.38 | Inhibition of Plasmodium falciparum protein farnesyltransferase by scintillation... | 17722901 |
| Unchecked | IC50 | = | 41.69 | nM | 7.38 | Inhibition of Plasmodium falciparum PFT | 18329140 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722901 | 10.1021/jm0703340 | Unchecked | 4 |
| 17722901 | 10.1021/jm0703340 | Plasmodium falciparum | 2 |
| 18329140 | 10.1016/j.ejmech.2008.01.025 | Unchecked | 2 |
| 18329140 | 10.1016/j.ejmech.2008.01.025 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine