Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1019540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat PFT
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: a comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity.
Gupta MK, Prabhakar YS.
Eur J Med Chem (2008) 43 : 2751 -2767
PubMed 18329140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 8.20 9.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL181102 1 9.16
CHEMBL193034 1 9.10
CHEMBL182888 1 8.92
CHEMBL183536 1 8.92
CHEMBL194447 1 8.82
CHEMBL373337 1 8.75
CHEMBL365742 1 8.52
CHEMBL370298 1 8.50
CHEMBL191843 1 8.47
CHEMBL192244 1 8.42
CHEMBL192898 1 8.30
CHEMBL195168 1 8.22
CHEMBL233288 1 8.12
CHEMBL365549 1 8.00
CHEMBL372017 1 6.80
CHEMBL371408 1 6.36
CHEMBL193161 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL181102 IC50 = 0.6918 nM 9.16
CHEMBL193034 IC50 = 0.7943 nM 9.10
CHEMBL182888 IC50 = 1.202 nM 8.92
CHEMBL183536 IC50 = 1.202 nM 8.92
CHEMBL194447 IC50 = 1.514 nM 8.82
CHEMBL373337 IC50 = 1.778 nM 8.75
CHEMBL365742 IC50 = 3.02 nM 8.52
CHEMBL370298 IC50 = 3.162 nM 8.50
CHEMBL191843 IC50 = 3.388 nM 8.47
CHEMBL192244 IC50 = 3.802 nM 8.42
CHEMBL192898 IC50 = 5.012 nM 8.30
CHEMBL195168 IC50 = 6.026 nM 8.22
CHEMBL233288 IC50 = 7.586 nM 8.12
CHEMBL365549 IC50 = 10.0 nM 8.00
CHEMBL372017 IC50 = 158.49 nM 6.80
CHEMBL371408 IC50 = 436.52 nM 6.36
CHEMBL193161 IC50 = 1000.0 nM 6.00