Assay Detail
Binding
CHEMBL896243
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Inhibition of Plasmodium falciparum protein farnesyltransferase by scintillation proximity assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.62 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539862 | — | — | 1 | 9.54 |
| CHEMBL183499 | — | — | 1 | 9.40 |
| CHEMBL395222 | — | — | 1 | 9.30 |
| CHEMBL232523 | — | — | 1 | 9.30 |
| CHEMBL232104 | — | — | 1 | 9.24 |
| CHEMBL394086 | — | — | 1 | 9.22 |
| CHEMBL399827 | — | — | 1 | 9.22 |
| CHEMBL393970 | — | — | 1 | 9.19 |
| CHEMBL265603 | — | — | 1 | 9.12 |
| CHEMBL429443 | — | — | 1 | 9.10 |
| CHEMBL233743 | — | — | 1 | 9.05 |
| CHEMBL233921 | — | — | 1 | 9.05 |
| CHEMBL394085 | — | — | 1 | 8.92 |
| CHEMBL392237 | — | — | 1 | 8.85 |
| CHEMBL232122 | — | — | 1 | 8.70 |
| CHEMBL233941 | — | — | 1 | 8.62 |
| CHEMBL558175 | — | — | 1 | 8.57 |
| CHEMBL234151 | — | — | 1 | 8.52 |
| CHEMBL234561 | — | — | 1 | 8.30 |
| CHEMBL394407 | — | — | 1 | 8.15 |
| CHEMBL192898 | — | — | 1 | 8.10 |
| CHEMBL233288 | — | — | 1 | 7.38 |
| CHEMBL232877 | — | — | 1 | 6.10 |
| CHEMBL234359 | — | — | 1 | 6.05 |
| CHEMBL438670 | — | — | 1 | - |
| CHEMBL233496 | — | — | 1 | - |
| CHEMBL233712 | — | — | 1 | - |
| CHEMBL233919 | — | — | 1 | - |
| CHEMBL233819 | — | — | 1 | - |
| CHEMBL233920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539862 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL183499 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL395222 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL232523 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL232104 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL394086 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL399827 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL393970 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL265603 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL429443 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL233743 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL233921 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL394085 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL392237 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL232122 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL233941 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL558175 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL234151 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL234561 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL394407 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL192898 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL233288 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL232877 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL234359 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL438670 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL233496 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL233712 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL233919 | — | IC50 | = | - | nM | - |
| CHEMBL233819 | — | IC50 | = | - | nM | - |
| CHEMBL233920 | — | IC50 | = | - | nM | - |
| CHEMBL234129 | — | IC50 | = | - | nM | - |