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Assay Detail

CHEMBL1019589

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to CCR3 receptor
16
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

C-C chemokine receptor type 3 (CHEMBL3473)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.
Dhar TG, Yang G, Davies P, Malley MF, Gougoutas JZ, Wu DR, Barrish JC, Carter PH.
Bioorg Med Chem Lett (2009) 19 : 96 -99
PubMed 19010676 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.91 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL518571 1 9.92
CHEMBL505914 1 9.82
CHEMBL461445 2 9.74
CHEMBL464902 1 9.64
CHEMBL399495 1 9.52
CHEMBL465272 3 9.43
CHEMBL465291 1 8.96
CHEMBL410959 1 8.92
CHEMBL363840 1 8.70
CHEMBL465942 1 8.68
CHEMBL468695 2 8.26
CHEMBL465943 1 8.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL518571 IC50 = 0.12 nM 9.92
CHEMBL505914 IC50 = 0.15 nM 9.82
CHEMBL461445 IC50 = 0.18 nM 9.74
CHEMBL464902 IC50 = 0.23 nM 9.64
CHEMBL399495 IC50 = 0.3 nM 9.52
CHEMBL465272 IC50 = 0.37 nM 9.43
CHEMBL461445 IC50 = 0.47 nM 9.33
CHEMBL465291 IC50 = 1.1 nM 8.96
CHEMBL410959 IC50 = 1.2 nM 8.92
CHEMBL363840 IC50 = 2.0 nM 8.70
CHEMBL465942 IC50 = 2.1 nM 8.68
CHEMBL465272 IC50 = 5.4 nM 8.27
CHEMBL468695 IC50 = 5.5 nM 8.26
CHEMBL465943 IC50 = 9.2 nM 8.04
CHEMBL465272 IC50 = 13.0 nM 7.89
CHEMBL468695 IC50 = 44.0 nM 7.36