Assay Detail
Binding
CHEMBL1019666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of VDR in human THP1 cells assessed as increase in 25-hydroxyvitamin D-24-hydroxylase mRNA expression by RT-PCR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.78 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494338 | — | — | 1 | 9.17 |
| CHEMBL492749 | — | — | 1 | 9.16 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494338 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL492749 | — | EC50 | = | 0.69 | nM | 9.16 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 10.0 | nM | 8.00 |