Assay Detail
Binding
CHEMBL1019871
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Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein
45
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cell division cycle 7-related protein kinase (CHEMBL5443) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 8.13 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445340 | — | — | 3 | 9.00 |
| CHEMBL495757 | — | — | 1 | 8.70 |
| CHEMBL524266 | — | — | 1 | 8.70 |
| CHEMBL497995 | — | — | 3 | 8.70 |
| CHEMBL496961 | — | — | 1 | 8.70 |
| CHEMBL447369 | — | — | 1 | 8.70 |
| CHEMBL496772 | — | — | 1 | 8.52 |
| CHEMBL509776 | — | — | 1 | 8.52 |
| CHEMBL443669 | — | — | 1 | 8.52 |
| CHEMBL459285 | — | — | 1 | 8.52 |
| CHEMBL451213 | — | — | 1 | 8.40 |
| CHEMBL526092 | — | — | 3 | 8.40 |
| CHEMBL449372 | — | — | 1 | 8.30 |
| CHEMBL525775 | — | — | 1 | 8.30 |
| CHEMBL451570 | — | — | 1 | 8.30 |
| CHEMBL444154 | — | — | 1 | 8.22 |
| CHEMBL459284 | — | — | 1 | 8.22 |
| CHEMBL459283 | — | — | 1 | 8.22 |
| CHEMBL402272 | — | — | 1 | 8.15 |
| CHEMBL498207 | — | — | 1 | 8.15 |
| CHEMBL495953 | — | — | 1 | 8.10 |
| CHEMBL495947 | — | — | 1 | 8.00 |
| CHEMBL498200 | — | — | 3 | 8.00 |
| CHEMBL513429 | — | — | 1 | 8.00 |
| CHEMBL225519 | — | — | 1 | 8.00 |
| CHEMBL523902 | — | — | 1 | 7.96 |
| CHEMBL522717 | — | — | 1 | 7.92 |
| CHEMBL496560 | — | — | 1 | 7.92 |
| CHEMBL449148 | — | — | 1 | 7.89 |
| CHEMBL522578 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445340 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL495757 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL496961 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL497995 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL447369 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL524266 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL459285 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL443669 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL509776 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL496772 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL526092 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL451213 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL445340 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL525775 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL449372 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL526092 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL451570 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL497995 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL526092 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL459284 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL444154 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL459283 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL498207 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL402272 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL495953 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL513429 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL498200 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL495947 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL225519 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL498200 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL523902 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL497995 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL498200 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL496560 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL522717 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL445340 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL449148 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL522578 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL512744 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL522398 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL495750 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL496773 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL495539 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL522890 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL495556 | — | IC50 | = | 64.0 | nM | 7.19 |