Cell division cycle 7-related protein kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Cell division cycle 7-related protein kinase shows clinical signal disease relevance led by neoplasm. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt O00311. Start with neoplasm, then reuse UniProt O00311 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt O00311 as the stable protein anchor across project notes and exports.
Cell division cycle 7-related protein kinase shows clinical signal disease relevance led by neoplasm. 2 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include NMS-1116354, SIMUROSERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCell division cycle 7-related protein kinase
Review this target as Cell division cycle 7-related protein kinase, mapped to UniProt O00311. Sequence length is 574 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cell division cycle 7-related protein kinase as ChEMBL target CHEMBL5443, mapped to UniProt O00311. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Cell division cycle 7-related protein kinase is the right protein anchor across sources, using UniProt O00311 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
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| Preferred Name | Cell division cycle 7-related protein kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O00311 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cell division cycle 7-related protein kinase |
| UniProt Accession | O00311 |
| Component Type | Protein |
| Sequence Length | 574 aa |
Cell division cycle 7-related protein kinase
Review this target as Cell division cycle 7-related protein kinase, mapped to UniProt O00311. Sequence length is 574 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Cell division cycle 7-related protein kinase shows clinical signal disease relevance led by neoplasm.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include NMS-1116354, SIMUROSERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1964519 | 9.9 | Ki | 0.1259 | Preclinical |
| CHEMBL244793 | 9.9 | Ki | 0.1259 | Preclinical |
| CHEMBL2062936 | 9.8 | Ki | 0.1585 | Preclinical |
| CHEMBL1986943 | 9.8 | Ki | 0.1585 | Preclinical |
| CHEMBL2005509 | 9.8 | Ki | 0.1585 | Preclinical |
| CHEMBL1992220 | 9.7 | Ki | 0.1995 | Preclinical |
| CHEMBL1965660 | 9.7 | Ki | 0.1995 | Preclinical |
| CHEMBL1980562 | 9.6 | Ki | 0.2512 | Preclinical |
| CHEMBL1958408 | 9.55 | Ki | 0.28 | Preclinical |
| CHEMBL1969151 | 9.5 | Ki | 0.3162 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 63 | 345 | 7.5 |
| cell-based format | 41 | 56 | 6.4 |
| assay format | 2 | 29 | 7.6 |
| subcellular format | 1 | 2 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 247 | 7.7 |