Assay Detail
Binding
CHEMBL1019883
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Displacement of [3H]U69593 form kappa opioid receptor in guinea pig brain
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.69 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2367604 | — | — | 1 | 10.05 |
| CHEMBL517166 | — | — | 1 | 10.05 |
| CHEMBL55033 | — | — | 1 | 9.21 |
| CHEMBL461229 | — | — | 1 | 9.15 |
| CHEMBL2107292 | KETAZOCINE | 2.0 | 1 | 9.00 |
| CHEMBL464071 | — | — | 1 | 8.82 |
| CHEMBL511691 | — | — | 1 | 8.74 |
| CHEMBL459746 | — | — | 1 | 8.55 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.62 |
| CHEMBL505011 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2367604 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL517166 | — | Ki | = | 0.089 | nM | 10.05 |
| CHEMBL55033 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL461229 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL2107292 | KETAZOCINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL464071 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL511691 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL459746 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL70 | MORPHINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL505011 | — | Ki | = | 2000.0 | nM | 5.70 |