Assay Detail
Binding
CHEMBL1019894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST fused Bcl-2 binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.30 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508392 | — | — | 1 | 7.52 |
| CHEMBL503454 | — | — | 1 | 7.00 |
| CHEMBL473446 | — | — | 1 | 6.89 |
| CHEMBL504480 | — | — | 1 | 6.89 |
| CHEMBL481581 | — | — | 1 | 6.80 |
| CHEMBL509788 | — | — | 1 | 6.68 |
| CHEMBL449546 | — | — | 1 | 6.57 |
| CHEMBL509208 | — | — | 1 | 6.48 |
| CHEMBL518649 | — | — | 1 | 6.42 |
| CHEMBL460173 | — | — | 1 | 6.32 |
| CHEMBL451856 | — | — | 1 | 6.29 |
| CHEMBL502066 | — | — | 1 | 6.22 |
| CHEMBL498873 | — | — | 1 | 6.19 |
| CHEMBL481775 | — | — | 1 | 6.16 |
| CHEMBL467229 | — | — | 1 | 6.11 |
| CHEMBL513318 | — | — | 1 | 5.70 |
| CHEMBL450954 | — | — | 1 | 5.50 |
| CHEMBL446802 | — | — | 1 | 5.25 |
| CHEMBL520607 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508392 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL503454 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL473446 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL504480 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL481581 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL509788 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL449546 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL509208 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL518649 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL460173 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL451856 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL502066 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL498873 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL481775 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL467229 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL513318 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL450954 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL446802 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL520607 | — | IC50 | = | 17300.0 | nM | 4.76 |