Compound Detail
CHEMBL460173
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1c(Cl)c(C(=O)N(c2ccccc2)c2ccccc2)nn1-c1ccccc1C(=O)N1Cc2ccccc2C[C@H]1CO
Basic Information
| ChEMBL ID | CHEMBL460173 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ITMKSGOOPACEDG-NDEPHWFRSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
577.1
MW (Da)
6.37
ALogP
5
HBA
1
HBD
78.7
PSA (Ų)
0.25
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Apoptosis regulator Bcl-2 CHEMBL4860 | IC50 | 7.3 | 6.81 | 50.0 | 2 |
| Bcl2-associated agonist of cell death CHEMBL3817 | IC50 | 5.64 | 5.64 | 2280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Apoptosis regulator Bcl-2 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of GST fused Bcl-2 binding to biotinylated 16 mer Bak-BH3 peptide by ... | 19027294 |
| Apoptosis regulator Bcl-2 | IC50 | = | 480.0 | nM | 6.32 | Inhibition of GST fused Bcl-2 binding to biotinylated 26 mer Bak-BH3 peptide by ... | 19027294 |
| Bcl2-associated agonist of cell death | IC50 | = | 2280.0 | nM | 5.64 | Inhibition of GST fused Bcl-xL binding to biotinylated 16 mer Bak-BH3 peptide by... | 19027294 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19027294 | 10.1016/j.bmcl.2008.10.113 | Apoptosis regulator Bcl-2 | 2 |
| 19027294 | 10.1016/j.bmcl.2008.10.113 | Bcl2-associated agonist of cell death | 2 |
Data from ChEMBL 36 via Core Engine