Assay Detail
Binding
CHEMBL1019893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST fused Bcl-xL binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bcl2-associated agonist of cell death (CHEMBL3817) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.29 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481581 | — | — | 1 | 6.60 |
| CHEMBL503454 | — | — | 1 | 5.79 |
| CHEMBL460173 | — | — | 1 | 5.64 |
| CHEMBL509788 | — | — | 1 | 5.62 |
| CHEMBL516633 | — | — | 1 | 5.39 |
| CHEMBL453466 | — | — | 1 | 5.29 |
| CHEMBL514298 | — | — | 1 | 5.28 |
| CHEMBL501871 | — | — | 1 | 5.25 |
| CHEMBL500574 | — | — | 1 | 5.17 |
| CHEMBL510332 | — | — | 1 | 5.01 |
| CHEMBL453380 | — | — | 1 | 4.95 |
| CHEMBL517577 | — | — | 1 | 4.91 |
| CHEMBL500866 | — | — | 1 | 4.90 |
| CHEMBL464268 | — | — | 1 | 4.78 |
| CHEMBL446480 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481581 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL503454 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL460173 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL509788 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL516633 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL453466 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL514298 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL501871 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL500574 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL510332 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL453380 | — | IC50 | = | 11360.0 | nM | 4.95 |
| CHEMBL517577 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL500866 | — | IC50 | = | 12630.0 | nM | 4.90 |
| CHEMBL464268 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL446480 | — | IC50 | = | 18000.0 | nM | 4.75 |