Compound Detail
CHEMBL510332
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CC(=O)NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)cc1C
Basic Information
| ChEMBL ID | CHEMBL510332 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FPIRBGHECAJMHS-HKBQPEDESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
583.7
MW (Da)
5.86
ALogP
5
HBA
1
HBD
87.5
PSA (Ų)
0.26
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Apoptosis regulator Bcl-2 CHEMBL4860 | IC50 | 6.14 | 6.14 | 730.0 | 1 |
| Bcl2-associated agonist of cell death CHEMBL3817 | IC50 | 5.01 | 5.01 | 9690.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Apoptosis regulator Bcl-2 | IC50 | = | 730.0 | nM | 6.14 | Inhibition of GST fused Bcl-2 binding to biotinylated 16 mer Bak-BH3 peptide by ... | 19027294 |
| Bcl2-associated agonist of cell death | IC50 | = | 9690.0 | nM | 5.01 | Inhibition of GST fused Bcl-xL binding to biotinylated 16 mer Bak-BH3 peptide by... | 19027294 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19027294 | 10.1016/j.bmcl.2008.10.113 | Apoptosis regulator Bcl-2 | 1 |
| 19027294 | 10.1016/j.bmcl.2008.10.113 | Bcl2-associated agonist of cell death | 1 |
Data from ChEMBL 36 via Core Engine