Assay Detail
Binding
CHEMBL1019939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Flavobacterium meningosepticum PEP
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Elizabethkingia meningoseptica |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Chymotrypsin-like elastase family member 1 (CHEMBL3000) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.13 | 7.29 |
| Ki | 1 | 6.54 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | — | 1 | 7.29 |
| CHEMBL465606 | — | — | 2 | 6.54 |
| CHEMBL2448554 | — | — | 1 | 5.96 |
| CHEMBL515528 | — | — | 1 | 5.90 |
| CHEMBL458248 | POLYOZELLIN | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL465606 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL2448554 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL465606 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL515528 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL458248 | POLYOZELLIN | IC50 | = | 2720.0 | nM | 5.57 |