Assay Detail
Functional
CHEMBL1020405
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Antiviral activity against HIV1 BaL in human PBMC assessed as blockade of reverse transcriptase activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.92 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206031 | BRECANAVIR | 2.0 | 1 | 9.38 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.55 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.36 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.44 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.24 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206031 | BRECANAVIR | EC50 | = | 0.42 | nM | 9.38 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL222559 | TIPRANAVIR | EC50 | = | 304.0 | nM | 6.52 |