Assay Detail
Functional
CHEMBL1020427
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Antiviral activity against HIV1 NL4-3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.29 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206031 | BRECANAVIR | 2.0 | 1 | 9.74 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 9.11 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.36 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 8.01 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.86 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.82 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206031 | BRECANAVIR | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 13.7 | nM | 7.86 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 15.3 | nM | 7.82 |
| CHEMBL222559 | TIPRANAVIR | EC50 | = | 76.2 | nM | 7.12 |