Assay Detail
Functional
CHEMBL1021519
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Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.41 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525809 | — | — | 1 | 8.65 |
| CHEMBL230333 | NEUROPEPTIDE S | — | 1 | 8.65 |
| CHEMBL526355 | — | — | 1 | 7.86 |
| CHEMBL505657 | — | — | 1 | 7.18 |
| CHEMBL526492 | — | — | 1 | 7.15 |
| CHEMBL507881 | — | — | 1 | 7.06 |
| CHEMBL526323 | — | — | 1 | 6.64 |
| CHEMBL525398 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525809 | — | EC50 | = | 2.239 | nM | 8.65 |
| CHEMBL230333 | NEUROPEPTIDE S | EC50 | = | 2.239 | nM | 8.65 |
| CHEMBL526355 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL505657 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL526492 | — | EC50 | = | 70.79 | nM | 7.15 |
| CHEMBL507881 | — | EC50 | = | 87.1 | nM | 7.06 |
| CHEMBL526323 | — | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL525398 | — | EC50 | = | 776.25 | nM | 6.11 |