Compound Detail
CHEMBL230333
NEUROPEPTIDE S Enter ChEMBL ID:
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CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL230333 |
| Name | NEUROPEPTIDE S |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | ZRCUKBVXFDZBKP-XJEBPGRNSA-N |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
2187.5
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 7 meas. best 9.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide S receptor CHEMBL5162 | EC50 | 9.17 | 9.12 | 0.7 | 2 |
| Neuropeptide S receptor CHEMBL5497 | EC50 | 8.96 | 8.378 | 1.1 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21466221 | 10.1021/jm200138r | Neuropeptide S receptor | 6 |
| 19113861 | 10.1021/jm8012294 | Neuropeptide S receptor | 3 |
| 19113861 | 10.1021/jm8012294 | Mus musculus | 3 |
| 17696420 | 10.1021/jm0706822 | Neuropeptide S receptor | 2 |
| 18181564 | 10.1021/jm701204n | Neuropeptide S receptor | 2 |
| 18793857 | 10.1016/j.bmc.2008.08.073 | Neuropeptide S receptor | 2 |
| 19473027 | 10.1021/jm900604g | Neuropeptide S receptor | 2 |
Data from ChEMBL 36 via Core Engine