Assay Detail
Functional
CHEMBL895978
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Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.61 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425840 | — | — | 1 | 8.17 |
| CHEMBL230333 | NEUROPEPTIDE S | — | 1 | 8.04 |
| CHEMBL390860 | — | — | 1 | 7.99 |
| CHEMBL437838 | — | — | 1 | 7.82 |
| CHEMBL428331 | — | — | 1 | 7.72 |
| CHEMBL230108 | — | — | 1 | 7.67 |
| CHEMBL437764 | — | — | 1 | 7.63 |
| CHEMBL438866 | — | — | 1 | 7.63 |
| CHEMBL438115 | — | — | 1 | 7.61 |
| CHEMBL229994 | — | — | 1 | 7.58 |
| CHEMBL263801 | — | — | 1 | 7.55 |
| CHEMBL396531 | — | — | 1 | 6.80 |
| CHEMBL267479 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425840 | — | EC50 | = | 6.761 | nM | 8.17 |
| CHEMBL230333 | NEUROPEPTIDE S | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL390860 | — | EC50 | = | 10.23 | nM | 7.99 |
| CHEMBL437838 | — | EC50 | = | 15.14 | nM | 7.82 |
| CHEMBL428331 | — | EC50 | = | 19.05 | nM | 7.72 |
| CHEMBL230108 | — | EC50 | = | 21.38 | nM | 7.67 |
| CHEMBL437764 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL438866 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL438115 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL229994 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL263801 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL396531 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL267479 | — | EC50 | = | 190.55 | nM | 6.72 |