Assay Detail
Functional
CHEMBL1021563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells after 72 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.47 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.64 |
| CHEMBL498271 | — | — | 1 | 8.60 |
| CHEMBL452175 | — | — | 1 | 8.52 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.50 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.48 |
| CHEMBL498108 | — | — | 1 | 7.47 |
| CHEMBL498107 | — | — | 1 | 7.42 |
| CHEMBL498106 | — | — | 1 | 6.07 |
| CHEMBL498447 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL498271 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL452175 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL107 | COLCHICINE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL498108 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL498107 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL498106 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL498447 | — | IC50 | = | 2800.0 | nM | 5.55 |