Assay Detail
Functional
CHEMBL1021863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dog recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-3 adrenergic receptor (CHEMBL4400) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.61 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486051 | — | — | 1 | 9.72 |
| CHEMBL507506 | — | — | 1 | 9.29 |
| CHEMBL488224 | — | — | 1 | 8.89 |
| CHEMBL271945 | — | — | 1 | 8.54 |
| CHEMBL487682 | — | — | 1 | 8.49 |
| CHEMBL453047 | — | — | 1 | 8.43 |
| CHEMBL470292 | — | — | 1 | 7.96 |
| CHEMBL59765 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486051 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL507506 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL488224 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL271945 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL487682 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL453047 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL470292 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL59765 | — | EC50 | = | 30.0 | nM | 7.52 |