Assay Detail
Functional
CHEMBL1021864
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Inhibition of carbachol-induced increase in intravesical pressure in intraduodenally dosed Beagle dog OAB model for 180 mins
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 8 | - | - |
| EC50 | 8 | 8.20 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507506 | — | — | 2 | 9.55 |
| CHEMBL487682 | — | — | 2 | 8.74 |
| CHEMBL486051 | — | — | 2 | 8.60 |
| CHEMBL488224 | — | — | 2 | 8.40 |
| CHEMBL470292 | — | — | 2 | 8.11 |
| CHEMBL453047 | — | — | 2 | 8.02 |
| CHEMBL271945 | — | — | 2 | 7.70 |
| CHEMBL59765 | — | — | 2 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507506 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL487682 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL486051 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL488224 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL470292 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL453047 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL271945 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL59765 | — | EC50 | = | 352.0 | nM | 6.45 |
| CHEMBL507506 | — | ED50 | = | 0.0048 | mg.kg-1 | - |
| CHEMBL271945 | — | ED50 | = | 0.0259 | mg.kg-1 | - |
| CHEMBL453047 | — | ED50 | = | 0.02 | mg.kg-1 | - |
| CHEMBL486051 | — | ED50 | = | 0.0035 | mg.kg-1 | - |
| CHEMBL487682 | — | ED50 | = | 0.0161 | mg.kg-1 | - |
| CHEMBL488224 | — | ED50 | = | 0.065 | mg.kg-1 | - |
| CHEMBL470292 | — | ED50 | = | 0.0284 | mg.kg-1 | - |
| CHEMBL59765 | — | ED50 | = | 0.27 | mg.kg-1 | - |