Assay Detail
Binding
CHEMBL1021960
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Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.89 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492175 | — | — | 1 | 6.84 |
| CHEMBL491348 | — | — | 1 | 4.49 |
| CHEMBL523822 | — | — | 1 | 4.18 |
| CHEMBL470707 | — | — | 1 | 4.04 |
| CHEMBL521636 | — | — | 1 | - |
| CHEMBL521771 | — | — | 1 | - |
| CHEMBL513042 | — | — | 1 | - |
| CHEMBL471915 | — | — | 1 | - |
| CHEMBL423112 | — | — | 1 | - |
| CHEMBL490920 | — | — | 1 | - |
| CHEMBL2368566 | — | — | 1 | - |
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492175 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL491348 | — | IC50 | = | 32570.0 | nM | 4.49 |
| CHEMBL523822 | — | IC50 | = | 66520.0 | nM | 4.18 |
| CHEMBL470707 | — | IC50 | = | 91760.0 | nM | 4.04 |
| CHEMBL521636 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL521771 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL513042 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL471915 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423112 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490920 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2368566 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL296588 | PEPSTATIN | IC50 | > | 100000.0 | nM | - |