Assay Detail
Binding
CHEMBL1021976
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Inhibition of cathepsin G by spectrofluorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.67 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452483 | GUTTIFERONE A | — | 1 | 5.57 |
| CHEMBL470519 | EPICLUSIANONE | — | 1 | 4.42 |
| CHEMBL470520 | GARCINIAPHENONE | — | 1 | 4.01 |
| CHEMBL470701 | — | — | 1 | - |
| CHEMBL90039 | BENZOPHENONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452483 | GUTTIFERONE A | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL470519 | EPICLUSIANONE | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL470520 | GARCINIAPHENONE | IC50 | = | 97600.0 | nM | 4.01 |
| CHEMBL470701 | — | IC50 | = | 433200.0 | nM | - |
| CHEMBL90039 | BENZOPHENONE | IC50 | - | — | - |