Assay Detail
Binding
CHEMBL1021994
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Inhibition of cathepsin K
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.49 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470915 | — | — | 1 | 8.70 |
| CHEMBL474484 | — | — | 1 | 8.22 |
| CHEMBL514805 | — | — | 1 | 8.05 |
| CHEMBL472618 | — | — | 1 | 7.89 |
| CHEMBL474829 | — | — | 1 | 7.85 |
| CHEMBL471757 | — | — | 1 | 7.77 |
| CHEMBL450061 | — | — | 1 | 7.75 |
| CHEMBL471951 | — | — | 1 | 7.66 |
| CHEMBL471584 | — | — | 1 | 7.64 |
| CHEMBL474828 | — | — | 1 | 7.62 |
| CHEMBL474830 | — | — | 1 | 7.50 |
| CHEMBL470916 | — | — | 1 | 7.22 |
| CHEMBL474831 | — | — | 1 | 7.21 |
| CHEMBL471578 | — | — | 1 | 6.96 |
| CHEMBL470897 | — | — | 1 | 6.52 |
| CHEMBL446519 | — | — | 1 | 6.47 |
| CHEMBL471579 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470915 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL474484 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL514805 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL472618 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL474829 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL471757 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL450061 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL471951 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL471584 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL474828 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL474830 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL470916 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL474831 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL471578 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL470897 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL446519 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL471579 | — | IC50 | = | 560.0 | nM | 6.25 |