Assay Detail
Binding
CHEMBL1021995
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Inhibition of cathepsin S
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.11 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450061 | — | — | 1 | 6.25 |
| CHEMBL474484 | — | — | 1 | 6.05 |
| CHEMBL471757 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450061 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL474484 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL471757 | — | IC50 | = | 910.0 | nM | 6.04 |