Assay Detail
Binding
CHEMBL1022112
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Activity at RARbeta1 expressed in mouse NIH3T3 cells by R-SAT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.48 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.60 |
| CHEMBL69367 | — | — | 1 | 7.30 |
| CHEMBL198794 | — | — | 1 | 6.50 |
| CHEMBL524687 | — | — | 1 | 6.40 |
| CHEMBL198997 | — | — | 1 | 6.40 |
| CHEMBL470587 | — | — | 1 | 6.00 |
| CHEMBL471422 | — | — | 1 | 5.90 |
| CHEMBL425027 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL69367 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL198794 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL524687 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL198997 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL470587 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL471422 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL425027 | — | EC50 | = | 1995.26 | nM | 5.70 |