Compound Detail
CHEMBL524687
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Basic Information
| ChEMBL ID | CHEMBL524687 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFRHSGSLZDXURB-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
328.4
MW (Da)
6.09
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.57
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor beta CHEMBL2008 | EC50 | 7.4 | 6.9 | 39.8 | 2 |
| Retinoic acid receptor gamma CHEMBL2003 | EC50 | 6.8 | 6.8 | 158.5 | 1 |
| Retinoic acid receptor alpha CHEMBL2055 | EC50 | 5.7 | 5.7 | 1995.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor beta | EC50 | = | 39.81 | nM | 7.4 | Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay | 19239230 |
| Retinoic acid receptor gamma | EC50 | = | 158.49 | nM | 6.8 | Activity at RARgamma expressed in mouse NIH3T3 cells by R-SAT assay | 19239230 |
| Retinoic acid receptor beta | EC50 | = | 398.11 | nM | 6.4 | Activity at RARbeta1 expressed in mouse NIH3T3 cells by R-SAT assay | 19239230 |
| Retinoic acid receptor alpha | EC50 | = | 1995.26 | nM | 5.7 | Activity at RARalpha expressed in mouse NIH3T3 cells by R-SAT assay | 19239230 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19239230 | 10.1021/jm801532e | Retinoic acid receptor beta | 4 |
| 19239230 | 10.1021/jm801532e | Retinoic acid receptor alpha | 2 |
| 19239230 | 10.1021/jm801532e | Retinoic acid receptor gamma | 2 |
Data from ChEMBL 36 via Core Engine