Assay Detail
Binding
CHEMBL1022116
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Activity at RARalpha expressed in mouse NIH3T3 cells by R-SAT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.43 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.20 |
| CHEMBL69367 | — | — | 1 | 7.10 |
| CHEMBL198997 | — | — | 1 | 6.20 |
| CHEMBL513760 | — | — | 1 | 5.80 |
| CHEMBL524687 | — | — | 1 | 5.70 |
| CHEMBL425027 | — | — | 1 | 5.60 |
| CHEMBL469281 | — | — | 1 | - |
| CHEMBL471422 | — | — | 1 | - |
| CHEMBL470588 | — | — | 1 | - |
| CHEMBL472476 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL69367 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL198997 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL513760 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL524687 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL425027 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL469281 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL471422 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL470588 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL472476 | — | EC50 | < | 10000.0 | nM | - |