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Assay Detail

CHEMBL1022170

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MAOB in rat brain mitochondria
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Subcellular Mitochondria
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2993)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Vilches-Herrera M, Miranda-Sepúlveda J, Rebolledo-Fuentes M, Fierro A, Lühr S, Iturriaga-Vasquez P, Cassels BK, Reyes-Parada M.
Bioorg Med Chem (2009) 17 : 2452 -2460
PubMed 19243954 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.08 6.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL456013 1 6.15
CHEMBL456006 1 5.59
CHEMBL450964 1 4.87
CHEMBL471840 1 4.87
CHEMBL443427 1 4.79
CHEMBL456005 1 4.65
CHEMBL510214 1 4.61
CHEMBL471838 1 -
CHEMBL471839 1 -
CHEMBL447882 1 -
CHEMBL455558 1 -
CHEMBL161985 1 -
CHEMBL455991 1 -
CHEMBL456012 1 -
CHEMBL457039 1 -
CHEMBL456841 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL456013 Ki = 710.0 nM 6.15
CHEMBL456006 Ki = 2560.0 nM 5.59
CHEMBL450964 Ki = 13600.0 nM 4.87
CHEMBL471840 Ki = 13500.0 nM 4.87
CHEMBL443427 Ki = 16300.0 nM 4.79
CHEMBL456005 Ki = 22200.0 nM 4.65
CHEMBL510214 Ki = 24700.0 nM 4.61
CHEMBL471838 Ki > 100000.0 nM -
CHEMBL471839 Ki > 100000.0 nM -
CHEMBL447882 Ki - -
CHEMBL455558 Ki - -
CHEMBL161985 Ki > 100000.0 nM -
CHEMBL455991 Ki > 100000.0 nM -
CHEMBL456012 Ki > 100000.0 nM -
CHEMBL457039 Ki > 100000.0 nM -
CHEMBL456841 Ki > 100000.0 nM -