Assay Detail
Binding
CHEMBL1022201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ACAT1 at 10 uM by liquid scintillography
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.80 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473384 | — | — | 1 | 5.28 |
| CHEMBL473967 | — | — | 1 | 4.92 |
| CHEMBL515415 | — | — | 1 | 4.75 |
| CHEMBL513992 | — | — | 1 | 4.75 |
| CHEMBL473385 | — | — | 1 | 4.55 |
| CHEMBL473982 | — | — | 1 | 4.54 |
| CHEMBL473386 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473384 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL473967 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL515415 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL513992 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL473385 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL473982 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL473386 | — | IC50 | > | 30000.0 | nM | - |