Assay Detail
Binding
CHEMBL1022246
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Reversible inhibition of Methanobacterium thermoautotrophicum ODCase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Methanothermobacter thermautotrophicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Orotidine 5'-phosphate decarboxylase (CHEMBL5688) ↗| Type | SINGLE PROTEIN |
| Organism | Methanobacterium thermoautotrophicum |
Publication
Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.54 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463623 | — | — | 1 | 6.70 |
| CHEMBL514166 | — | — | 1 | 6.44 |
| CHEMBL514137 | — | — | 1 | 6.08 |
| CHEMBL474165 | — | — | 1 | 4.94 |
| CHEMBL512577 | — | — | 1 | 4.54 |
| CHEMBL473587 | — | — | 1 | 4.54 |
| CHEMBL474163 | — | — | 1 | - |
| CHEMBL472783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463623 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL514166 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL514137 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL474165 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL512577 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL473587 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL474163 | — | Ki | = | 645000.0 | nM | - |
| CHEMBL472783 | — | Ki | = | 134000.0 | nM | - |