Orotidine 5'-phosphate decarboxylase · SINGLE PROTEIN · Methanobacterium thermoautotrophicum
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As of 2026-09-14Protein identity stays anchored to UniProt O26232. Use UniProt O26232 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O26232 as the stable identity anchor, then attach disease evidence before program review.
Orotidine 5'-phosphate decarboxylase
Review this target as Orotidine 5'-phosphate decarboxylase, mapped to UniProt O26232. Sequence length is 228 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Orotidine 5'-phosphate decarboxylase as ChEMBL target CHEMBL5688, mapped to UniProt O26232. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Orotidine 5'-phosphate decarboxylase |
| Target Type | SINGLE PROTEIN |
| Organism | Methanobacterium thermoautotrophicum |
| UniProt | O26232 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Orotidine 5'-phosphate decarboxylase |
| UniProt Accession | O26232 |
| Component Type | Protein |
| Sequence Length | 228 aa |
Orotidine 5'-phosphate decarboxylase
Review this target as Orotidine 5'-phosphate decarboxylase, mapped to UniProt O26232. Sequence length is 228 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL463623 | 6.7 | Ki | 200.0 | Preclinical |
| CHEMBL514166 | 6.44 | Ki | 360.0 | Preclinical |
| CHEMBL1765125 | 6.2 | Ki | 630.0 | Preclinical |
| CHEMBL514137 | 6.08 | Ki | 840.0 | Preclinical |
| CHEMBL1164953 | 5.21 | Ki | 6200.0 | Preclinical |
| CHEMBL2105330 | 5.21 | Ki | 6200.0 | Clinical |
| CHEMBL2178721 | 4.96 | Ki | 11100.0 | Preclinical |
| CHEMBL564201 | 4.96 | Ki | 11000.0 | Preclinical |
| CHEMBL474165 | 4.94 | Ki | 11400.0 | Preclinical |
| CHEMBL463480 | 4.91 | Ki | 12400.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 13 | 19 | 5.3 |
| assay format | 3 | 1 | 5.2 |