Compound Detail
CHEMBL2105330
PYRAZOFURIN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2105330 |
| Name | PYRAZOFURIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XESARGFCSKSFID-FLLFQEBCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
6
Known Names
Molecular Properties
259.2
MW (Da)
-2.63
ALogP
7
HBA
6
HBD
161.9
PSA (Ų)
0.35
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
Ki 2 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Uridine 5'-monophosphate synthase CHEMBL5216 | Ki | 7.77 | 7.77 | 17.0 | 1 |
| Orotidine 5'-phosphate decarboxylase CHEMBL5688 | Ki | 5.21 | 5.21 | 6200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Uridine 5'-monophosphate synthase | Ki | = | 17.0 | nM | 7.77 | Inhibition of human ODCase | 29277307 |
| Orotidine 5'-phosphate decarboxylase | Ki | = | 6200.0 | nM | 5.21 | Inhibition of Methanobacterium thermoautotrophicum ODCase | 29277307 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 18834112 | 10.1021/jm800656v | Amine oxidase [flavin-containing] A | 1 |
| 29277307 | 10.1016/j.bmc.2017.11.037 | Orotidine 5'-phosphate decarboxylase | 1 |
| 29277307 | 10.1016/j.bmc.2017.11.037 | Uridine 5'-monophosphate synthase | 1 |
Data from ChEMBL 36 via Core Engine