Assay Detail
Functional
CHEMBL1022253
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Antitumor activity against human SKW3 cells after 3 days by WST1 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKW3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.88 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463626 | — | — | 1 | 6.52 |
| CHEMBL512582 | — | — | 1 | 6.40 |
| CHEMBL464222 | — | — | 1 | 6.22 |
| CHEMBL464223 | — | — | 1 | 5.92 |
| CHEMBL463428 | — | — | 1 | 5.80 |
| CHEMBL463480 | 6-AZA-URIDINE MONOPHOSPHATE | — | 1 | 5.55 |
| CHEMBL220442 | — | — | 1 | 4.72 |
| CHEMBL383923 | — | — | 1 | - |
| CHEMBL267051 | — | — | 1 | - |
| CHEMBL399850 | — | — | 1 | - |
| CHEMBL255061 | — | — | 1 | - |
| CHEMBL439055 | — | — | 1 | - |
| CHEMBL512059 | — | — | 1 | - |
| CHEMBL462838 | — | — | 1 | - |
| CHEMBL255062 | — | — | 1 | - |
| CHEMBL447888 | — | — | 1 | - |
| CHEMBL512581 | — | — | 1 | - |
| CHEMBL464221 | — | — | 1 | - |
| CHEMBL504832 | — | — | 1 | - |
| CHEMBL452881 | — | — | 1 | - |
| CHEMBL401482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463626 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL512582 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL464222 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL464223 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL463428 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL463480 | 6-AZA-URIDINE MONOPHOSPHATE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL220442 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL383923 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL267051 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL399850 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL255061 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL439055 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL512059 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL462838 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL255062 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL447888 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL512581 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL464221 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL504832 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL452881 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL401482 | — | IC50 | > | 50000.0 | nM | - |