Assay Detail
Binding
CHEMBL1022257
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Inhibition of DPP4 in rat plasma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.82 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445437 | — | — | 1 | 9.89 |
| CHEMBL456420 | — | — | 1 | 9.77 |
| CHEMBL390513 | — | — | 1 | 7.52 |
| CHEMBL184651 | — | — | 1 | 6.11 |
| CHEMBL452425 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445437 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL456420 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL390513 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL184651 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL452425 | — | IC50 | = | 1560.0 | nM | 5.81 |