Assay Detail
Binding
CHEMBL1022422
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Inhibition of wild-type c-Abl by liquid scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.98 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.96 |
| CHEMBL475796 | — | — | 1 | 5.70 |
| CHEMBL493315 | — | — | 1 | 5.58 |
| CHEMBL1080580 | — | — | 1 | 5.57 |
| CHEMBL523684 | — | — | 1 | 5.42 |
| CHEMBL492956 | — | — | 1 | 5.35 |
| CHEMBL475820 | — | — | 1 | 5.28 |
| CHEMBL473826 | — | — | 1 | 5.11 |
| CHEMBL521652 | — | — | 1 | 5.05 |
| CHEMBL514351 | — | — | 1 | 5.04 |
| CHEMBL475051 | — | — | 1 | 4.77 |
| CHEMBL474863 | — | — | 1 | 4.62 |
| CHEMBL474208 | — | — | 1 | 4.62 |
| CHEMBL515109 | — | — | 1 | 4.62 |
| CHEMBL473825 | — | — | 1 | 4.60 |
| CHEMBL514511 | — | — | 1 | 4.51 |
| CHEMBL515258 | — | — | 1 | 4.50 |
| CHEMBL515432 | — | — | 1 | 4.47 |
| CHEMBL474046 | — | — | 1 | 4.46 |
| CHEMBL474015 | — | — | 1 | 4.41 |
| CHEMBL514671 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL475796 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL493315 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1080580 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL523684 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL492956 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL475820 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL473826 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL521652 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL514351 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL475051 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL474863 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL474208 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL515109 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL473825 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL514511 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL515258 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL515432 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL474046 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL474015 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL514671 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | > | 100000.0 | nM | - |