Assay Detail
Binding
CHEMBL1023015
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Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli by spectrophotometry
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (CHEMBL5926) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
Publication
Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.73 | 7.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552521 | — | — | 1 | 7.00 |
| CHEMBL366942 | — | — | 1 | 5.30 |
| CHEMBL464924 | — | — | 1 | 4.92 |
| CHEMBL67599 | — | — | 1 | 4.75 |
| CHEMBL464925 | — | — | 1 | 4.42 |
| CHEMBL266564 | TILIROSIDE | — | 1 | 4.34 |
| CHEMBL1231470 | CHALEPIN | — | 1 | 4.19 |
| CHEMBL465536 | — | — | 1 | 4.16 |
| CHEMBL474167 | — | — | 1 | 4.09 |
| CHEMBL464404 | CASTANIN | — | 1 | 4.08 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
| CHEMBL277156 | — | — | 1 | - |
| CHEMBL464825 | MANGIFERIN | — | 1 | - |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
| CHEMBL464507 | GUAJAVERIN | — | 1 | - |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552521 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL366942 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL464924 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL67599 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL464925 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL266564 | TILIROSIDE | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1231470 | CHALEPIN | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL465536 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL474167 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL464404 | CASTANIN | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL169 | URSOLIC ACID | Inhibition | = | 25.0 | % | - |
| CHEMBL6466 | COUMARIN | IC50 | = | 691830.0 | nM | - |
| CHEMBL277156 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL464825 | MANGIFERIN | IC50 | = | 149000.0 | nM | - |
| CHEMBL50 | QUERCETIN | IC50 | = | 142000.0 | nM | - |
| CHEMBL464507 | GUAJAVERIN | IC50 | = | 140000.0 | nM | - |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 616580.0 | nM | - |