Assay Detail
Binding
CHEMBL1023101
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Inhibition of QPP
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.93 | 8.57 |
| Ki | 1 | 6.90 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237336 | — | — | 1 | 8.57 |
| CHEMBL237119 | — | — | 1 | 7.62 |
| CHEMBL63860 | — | — | 1 | 6.90 |
| CHEMBL257023 | — | — | 1 | 6.48 |
| CHEMBL25437 | — | — | 1 | 5.06 |
| CHEMBL459357 | — | — | 1 | - |
| CHEMBL445949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237336 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL237119 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL63860 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL257023 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL25437 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL459357 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL445949 | — | IC50 | > | 100000.0 | nM | - |