Assay Detail
Functional
CHEMBL1023633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 8.25 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556891 | — | — | 1 | 10.70 |
| CHEMBL557293 | — | — | 1 | 10.70 |
| CHEMBL556892 | — | — | 1 | 10.40 |
| CHEMBL562509 | — | — | 1 | 10.30 |
| CHEMBL559974 | — | — | 1 | 9.30 |
| CHEMBL563716 | — | — | 1 | 9.22 |
| CHEMBL559580 | — | — | 1 | 9.22 |
| CHEMBL539459 | — | — | 1 | 9.15 |
| CHEMBL561713 | — | — | 1 | 8.89 |
| CHEMBL552108 | — | — | 1 | 8.52 |
| CHEMBL555562 | — | — | 1 | 8.40 |
| CHEMBL549554 | — | — | 1 | 8.35 |
| CHEMBL552156 | — | — | 1 | 8.33 |
| CHEMBL564782 | — | — | 1 | 8.22 |
| CHEMBL560248 | — | — | 1 | 8.17 |
| CHEMBL541973 | — | — | 1 | 8.02 |
| CHEMBL551972 | — | — | 1 | 7.96 |
| CHEMBL559581 | — | — | 1 | 7.85 |
| CHEMBL564015 | — | — | 1 | 7.46 |
| CHEMBL551305 | — | — | 1 | 6.86 |
| CHEMBL552107 | — | — | 1 | 6.80 |
| CHEMBL561712 | — | — | 1 | 6.71 |
| CHEMBL550170 | — | — | 1 | 6.57 |
| CHEMBL551782 | — | — | 1 | 6.42 |
| CHEMBL551784 | — | — | 1 | 6.22 |
| CHEMBL563070 | — | — | 1 | 5.78 |
| CHEMBL549624 | — | — | 1 | - |
| CHEMBL560647 | — | — | 1 | - |
| CHEMBL560249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556891 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL557293 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL556892 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL562509 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL559974 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL563716 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL559580 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL539459 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL561713 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL552108 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL555562 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL549554 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL552156 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL564782 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL560248 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL541973 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL551972 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL559581 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL564015 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL551305 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL552107 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL561712 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL550170 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL551782 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL551784 | — | EC50 | = | 606.0 | nM | 6.22 |
| CHEMBL563070 | — | EC50 | = | 1665.0 | nM | 5.78 |
| CHEMBL549624 | — | EC50 | - | — | - | |
| CHEMBL560647 | — | EC50 | - | — | - | |
| CHEMBL560249 | — | EC50 | - | — | - |