Assay Detail
Binding
CHEMBL1023736
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Inhibition of human recombinant ALR2 expressed in bacterial cell expression system
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.12 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 6.58 |
| CHEMBL273910 | MINALRESTAT | 2.0 | 1 | 6.55 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.23 |
| CHEMBL449129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL273910 | MINALRESTAT | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL50 | QUERCETIN | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL449129 | — | IC50 | = | 127000.0 | nM | - |