Assay Detail
Functional
CHEMBL1023998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiopyrano[2,3-e]indol-2-ones: angelicin heteroanalogues with potent photoantiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.19 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196028 | — | — | 1 | 6.05 |
| CHEMBL371273 | — | — | 1 | 5.27 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 5.11 |
| CHEMBL193565 | — | — | 1 | 4.96 |
| CHEMBL197313 | — | — | 1 | 4.95 |
| CHEMBL53569 | ANGELICIN | — | 1 | 4.80 |
| CHEMBL193926 | — | — | 1 | - |
| CHEMBL460825 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196028 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL371273 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL416 | METHOXSALEN | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL193565 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL197313 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL53569 | ANGELICIN | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL193926 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL460825 | — | IC50 | > | 20000.0 | nM | - |