Assay Detail
Binding
CHEMBL1024188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bee venom secretory PLA2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Apis mellifera |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.67 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470339 | PETROSASPONGIOLIDE M | — | 1 | 6.22 |
| CHEMBL463914 | MANOALIDE | — | 1 | 5.12 |
| CHEMBL499563 | PETROSASPONGIOLIDE N | — | 1 | - |
| CHEMBL496249 | PETROSASPONGIOLIDE P | — | 1 | - |
| CHEMBL512001 | — | — | 1 | - |
| CHEMBL514471 | — | — | 1 | - |
| CHEMBL474674 | PETROSASPONGIOLIDE Q | — | 1 | - |
| CHEMBL514134 | PETROSASPONGIOLIDE R | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470339 | PETROSASPONGIOLIDE M | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL463914 | MANOALIDE | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL499563 | PETROSASPONGIOLIDE N | IC50 | - | — | - | |
| CHEMBL496249 | PETROSASPONGIOLIDE P | IC50 | - | — | - | |
| CHEMBL512001 | — | IC50 | - | — | - | |
| CHEMBL514471 | — | IC50 | - | — | - | |
| CHEMBL474674 | PETROSASPONGIOLIDE Q | IC50 | - | — | - | |
| CHEMBL514134 | PETROSASPONGIOLIDE R | IC50 | - | — | - |