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Compound Detail

CHEMBL470339

PETROSASPONGIOLIDE M
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CC(=O)O[C@@H]1O[C@@H](C2=CC(=O)OC2O)C[C@@H]2[C@@H]1CC[C@H]1[C@@]2(C)CC[C@H]2C(C)(C)CCC[C@]12C

Basic Information

ChEMBL ID CHEMBL470339
Name PETROSASPONGIOLIDE M
Phase Preclinical
Structure Type MOL
InChI Key RVWQZLJUVIFAOY-GQLPRRODSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

460.6
MW (Da)
4.74
ALogP
6
HBA
1
HBD
82.1
PSA (Ų)
0.60
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C27H40O6
MW 460.61
Aromatic Rings 0
Heavy Atoms 33
NP-Likeness 3.30

Activity Summary

IC50 2 meas. best 6.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phospholipase A2
CHEMBL4807
IC50 6.22 6.22 600.0 1
Phospholipase A2
CHEMBL4426
IC50 5.8 5.8 1600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Phospholipase A2 IC50 = 600.0 nM 6.22 Inhibition of bee venom secretory PLA2 9599251
Phospholipase A2 IC50 = 1600.0 nM 5.8 Inhibition of human synovial secretory PLA2 9599251

Literature References

PubMed DOI Target Context # Activities
9599251 10.1021/np9704922 Phospholipase A2 4
17407277 10.1021/jm0700823 Phospholipase A2 2
17407277 10.1021/jm0700823 RAW264.7 2
17407277 10.1021/jm0700823 Acidic phospholipase A2 2 1
17407277 10.1021/jm0700823 Phospholipase A2, major isoenzyme 1
17407277 10.1021/jm0700823 Unchecked 1
9599251 10.1021/np9704922 Acidic phospholipase A2 2 1
9599251 10.1021/np9704922 Unchecked 1

Data from ChEMBL 36 via Core Engine