Assay Detail

CHEMBL1024334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HIV isolate 584.000 063 by replication assay

ChEMBL ↗

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Target

Human immunodeficiency virus (CHEMBL613758) ↗

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Primary target Human immunodeficiency virus

CHEMBL613758

Anchored from Assay target.

Protein identity Human immunodeficiency virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus (CHEMBL613758) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus

Publication

Heterobiaryl human immunodeficiency virus entry inhibitors.

Lu RJ, Tucker JA, Pickens J, Ma YA, Zinevitch T, Kirichenko O, Konoplev V, Kuznetsova S, Sviridov S, Brahmachary E, Khasanov A, Mikel C, Yang Y, Liu C, Wang J, Freel S, Fisher S, Sullivan A, Zhou J, Stanfield-Oakley S, Baker B, Sailstad J, Greenberg M, Bolognesi D, Bray B, Koszalka B, Jeffs P, Jeffries C, Chucholowski A, Sexton C.
J Med Chem (2009) 52 : 4481 -4487
PubMed 19534463 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.57	7.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL238103	—	—	1	7.77
CHEMBL549336	—	—	1	7.60
CHEMBL337301	—	—	1	7.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL238103	—	IC50	=	17.0	nM	7.77
CHEMBL549336	—	IC50	=	25.0	nM	7.60
CHEMBL337301	—	IC50	=	46.0	nM	7.34