Assay Detail
Functional
CHEMBL1024364
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Antiviral activity against Herpes simplex virus type 1 in HFF assessed as inhibition of virus-induced cytopathic effect
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.06 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.89 |
| CHEMBL554910 | — | — | 1 | 4.23 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | - |
| CHEMBL372938 | — | — | 1 | - |
| CHEMBL572812 | — | — | 1 | - |
| CHEMBL550615 | — | — | 1 | - |
| CHEMBL559499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL554910 | — | EC50 | = | 59400.0 | nM | 4.23 |
| CHEMBL265948 | FILOCICLOVIR | EC50 | > | 380000.0 | nM | - |
| CHEMBL372938 | — | EC50 | > | 301000.0 | nM | - |
| CHEMBL572812 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL550615 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL559499 | — | EC50 | > | 300000.0 | nM | - |