Assay Detail
Functional
CHEMBL1024481
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Protection against anthrax protective antigen-38/LF-induced cell death in mouse RAW264.7 cells pretreated for 2 hrs followed by PA38/LA challenge assessed as cell viability measured after 4 hrs by ATPlite assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.18 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551180 | — | — | 1 | 6.60 |
| CHEMBL563737 | — | — | 1 | 6.30 |
| CHEMBL558685 | — | — | 1 | 6.00 |
| CHEMBL559911 | — | — | 1 | 5.80 |
| CHEMBL559516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551180 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL563737 | — | EC50 | = | 506.0 | nM | 6.30 |
| CHEMBL558685 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL559911 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL559516 | — | EC50 | - | — | - |