Assay Detail
Functional
CHEMBL1024565
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Antiproliferative activity against human HL60 cells after 24 hrs
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.05 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212378 | — | — | 1 | 6.70 |
| CHEMBL565149 | — | — | 1 | 6.70 |
| CHEMBL455983 | — | — | 1 | 6.70 |
| CHEMBL559519 | — | — | 1 | 6.52 |
| CHEMBL557903 | — | — | 1 | 6.40 |
| CHEMBL563062 | — | — | 1 | 6.40 |
| CHEMBL559967 | — | — | 1 | 6.40 |
| CHEMBL558006 | — | — | 1 | 6.30 |
| CHEMBL551168 | — | — | 1 | 6.22 |
| CHEMBL551574 | — | — | 1 | 5.96 |
| CHEMBL550231 | — | — | 1 | 5.92 |
| CHEMBL551788 | — | — | 1 | 5.85 |
| CHEMBL273201 | — | — | 1 | 5.80 |
| CHEMBL551706 | — | — | 1 | 5.72 |
| CHEMBL550639 | — | — | 1 | 5.72 |
| CHEMBL562505 | — | — | 1 | 5.39 |
| CHEMBL559912 | — | — | 1 | 5.24 |
| CHEMBL558884 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212378 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL565149 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL455983 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL559519 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL557903 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL563062 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL559967 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL558006 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL551168 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL551574 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL550231 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL551788 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL273201 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL551706 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL550639 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL562505 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL559912 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL558884 | — | IC50 | = | 10800.0 | nM | 4.97 |