Assay Detail
Binding
CHEMBL1024694
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Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.39 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522152 | — | — | 1 | 7.76 |
| CHEMBL119709 | IB-MECA | — | 1 | 7.29 |
| CHEMBL200732 | — | — | 1 | 6.71 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 6.65 |
| CHEMBL500569 | — | — | 1 | 6.28 |
| CHEMBL522856 | — | — | 1 | 6.10 |
| CHEMBL494086 | — | — | 1 | 6.07 |
| CHEMBL493888 | — | — | 1 | 5.97 |
| CHEMBL509055 | — | — | 1 | 5.84 |
| CHEMBL436485 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522152 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL119709 | IB-MECA | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL200732 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL500569 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL522856 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL494086 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL493888 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL509055 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL436485 | — | Ki | = | 6220.0 | nM | 5.21 |