Assay Detail
Binding
CHEMBL1024697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cell membrane by liquid scintillation counting
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.21 | 8.85 |
| IC50 | 3 | 7.63 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 8.85 |
| CHEMBL448998 | — | — | 2 | 8.74 |
| CHEMBL507340 | — | — | 2 | 7.80 |
| CHEMBL389652 | — | — | 2 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL448998 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL448998 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL507340 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL389652 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL507340 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL389652 | — | IC50 | = | 79.43 | nM | 7.10 |